Partner News: Syntrix Pharmaceuticals

Partner News: Syntrix Pharmaceuticals
October 29, 2020 Laura Beauregard

Syntrix Completes Initial SX-682 Dosing in Broad Phase 1/2 Cancer Trial Campaign Now Encompassing 5 Solid Cancer Types Plus Myelodysplastic Syndromes

AUBURN, Wash., Oct. 27, 2020 /PRNewswire/ -- Syntrix Pharmaceuticals, a clinical-stage biotechnology company developing first-in-class product candidates focused on emerging immune control mechanisms in oncology indications, announced today it completed initial SX-682 dosing in Phase 1/2 trials in myelodysplastic syndromes (MDS) and metastatic melanoma. The drug was well tolerated and absorbed with excellent dose-proportional drug levels in blood. The trials are being conducted at the Moffitt Cancer Center, Massachusetts General Hospital, Dana-Farber Cancer Institute, Mayo Clinic and the University of Rochester.

There is a major need for new cancer treatments targeting novel immune control mechanisms in cancer since existing immunotherapies induce a durable response in only a small percentage of patients. SX-682 is the company's lead drug from its tumor-microenvironment (TME) discovery platform targeting key molecular pathways cancer uses to shield itself from immune attack. High-profile scientific publications from major cancer centers report SX-682 potently eradicates cancer and extends survival: National Cancer Institute (JCI Insight, J Immunother Cancer), Fred Hutchinson Cancer Research Institute (JCI Insight), and MD Anderson (Nature and Cancer Cell).

Based on these promising results, additional Phase 1/2 trials are now also opening for SX-682 in pancreatic cancer at the University of Rochester, in colorectal cancer at the MD Anderson Cancer Center, and in advanced tumors including breast and head and neck cancers at the National Institutes of Health Clinical Center.

"The CXCR1/2 pathway blocked by SX-682 suppresses anti-tumor immunity," said John Zebala, MD, PhD, president at Syntrix. "Patients with low CXCR1/2 activity survive significantly longer compared to patients with high activity. We are hopeful the same effect can be achieved by pharmacologically blocking the pathway with SX-682. We believe the breadth of the SX-682 clinical program positions it for major read-outs."

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Congratulations to DF/Net Research client, Syntrix on these promising results. It is a privilege to be involved in this important clinical research. Client successes like this one, motivate our team and reinforce our goal of supporting clinical trials with global impact.